Rubén Peña-Vélez, Unidad de Gastroenterología, Hepatología y Nutrición Pediátrica, Hospital General Dr. Eduardo Vázquez N., Servicios de Salud IMSS-BIENESTAR, Pue.; Departamento de Ciencias de la Salud, Universidad de las Américas Puebla, Pue., México
Melissa Zavala-Rodríguez, Unidad de Gastroenterología, Hepatología y Nutrición Pediátrica, Hospital General Dr. Eduardo Vázquez N., Servicios de Salud IMSS-BIENESTAR, Pue., México
Nadia Gutiérrez-Galicia, Unidad de Gastroenterología, Hepatología y Nutrición Pediátrica, Hospital General Dr. Eduardo Vázquez N., Servicios de Salud IMSS-BIENESTAR, Pue., México
Laura E. Flores-Fong, Servicio Gastroenterología y Nutrición Pediátrica, Hospital Civil de Guadalajara Dr. Juan I, Menchaca, Jal., México
Emmanuel Arce-Arce, Unidad de Gastroenterología, Hepatología y Nutrición Pediátrica, Hospital General Dr. Eduardo Vázquez N., Servicios de Salud IMSS-BIENESTAR, Pue., México
Background: It has been shown that there is an association between the history of allergy and the development of disorders of the gut-brain interaction (DGBI). The aim of this study was to evaluate the history of cow’s milk protein allergy (CMPA) in a group of children with DGBI. Methods: A case-control study. Fifty-two pediatric patients with any diagnosis included in DGBI according to Rome IV criteria were included and primary caregivers were questioned using a cow’s milk protein-related symptom scoring system during the first year of life. Results: The most frequently observed DGBI were constipation, dyspepsia, and irritable bowel syndrome. Pediatric patients with DGBI have a higher score of cow’s milk protein-related symptoms compared to controls (p < 0.001). Stool disturbances and crying were the highest-scoring symptoms in children with DGBI. Patients with a higher score had an odds ratio of 1.759 (95% CI: 1.376-2.247; p < 0.001) for having any diagnosis of DGBI. Conclusions: CMPA during the first year of life may be associated with the subsequent development of DGBI in pediatric patients.
Keywords: Milk allergy. Constipation. Dyspepsia. Irritable bowel syndrome.